PulmoScience Lab
Epithelial
CROss-talk
Epithelial - Immune
Emphysema
Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.
Epithelial - Immune
Tumor immunity
Using single cells and imaging CyToF technology and Lung-Chip cultures we aim to characterize the tumor immune landscape and identify host factors that contribute to recurrence.
Epithelial - Stromal
Emphysema
We use organoid technology to study epithelial-mesenchymal cross-talk in the emphysematous niche.
Epithelial - Endothelial
Alveolar repair
With use of Organoid and Lung-Chip technology we aim to establish the contribution of the microvascular lung endothelium to alveolar repair.
Epithelial - Microbe
SARS-CoV-2
Together with the departments of Medical Microbiology and CCB, we study SARS-CoV-2 biology in different regions of the lung and in comparison to other coronaviruses.
Epithelial - Microbe
Rhinovirus
We study host-virus infections with focus on Rhinovirus as an important contributor to COPD and asthma exacerbations. We study anti-viral immunity in patient-derived materials and for example in connection to whole cigarette smoke exposure.
Epithelial - Microbe
Farm Dust
Together with the department of Parasitology (dr. Hermelijn Smits) we investigate protective effects of farm dust exposure of the airway epithelium in the context of asthma.
Epithelial - Microbe
Mycobacterium tuberculosis
In collaboration with the group of Prof. Tom Ottenhoff, dr. Simone Joosten and Amy de Waal (Dept. of Infectious Diseases, LUMC), we study M. tuberculosis infection of bronchial and alveolar epithelial cells.
Epithelial - Microbe
Host Defense Peptides
In collaboration with the group of dr. Peter Nibbering (Dept. of Infectious Diseases, LUMC) we study the role of host defense peptides in antibiotic-resistant respiratory infections.
