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Epithelial

CROss-talk

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Epithelial - Immune

Emphysema

Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.

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Epithelial - Immune

Tumor immunity

Using single cells and imaging CyToF technology and Lung-Chip cultures we aim to characterize the tumor immune landscape and identify host factors that contribute to recurrence.

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Epithelial - Stromal

Emphysema

We use organoid technology to study epithelial-mesenchymal cross-talk in the emphysematous niche.

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Epithelial - Stromal

Alveolar repair

With use of Organoid and Lung-Chip technology we aim to establish the contribution of the microvascular lung endothelium to alveolar repair.

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Epithelial - Microbe

SARS-CoV-2

Together with the departments of Medical Microbiology and CCB, we study SARS-CoV-2 biology in different regions of the lung and in comparison to other coronaviruses.

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Epithelial - Microbe

Rhinovirus

We study host-virus infections with focus on Rhinovirus as an important contributor to COPD and asthma exacerbations. We study anti-viral immunity in patient-derived materials and for example in connection to whole cigarette smoke exposure.

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Epithelial - Microbe

Farm Dust

Together with the department of Parasitology (dr. Hermelijn Smits) we investigate protective effects of farm dust exposure of the airway epithelium in the context of asthma.

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Epithelial - Microbe

Mycobacterium tuberculosis

In collaboration with the group of Prof. Tom Ottenhoff, dr. Simone Joosten and Amy de Waal (Dept. of Infectious Diseases, LUMC), we study M. tuberculosis infection of bronchial and alveolar epithelial cells.

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Epithelial - Microbe

Host Defense Peptides

In collaboration with the group of dr. Peter Nibbering (Dept. of Infectious Diseases, LUMC) we study the role of host defense peptides in antibiotic-resistant respiratory infections.

Patrick Lennart
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