We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD and Asthma
We use Organoid and Transwell cultures to investigate the biology of radiation-induced lung fibrosis.
COVID-19 lung damage
We use primary alveolar cell cultures and organoid technology in combination with the Lung-Chip to develop a human cell culture model of COVID-19-related lung damage.
Using Lung-Chip technology combined with hiPSC and exposures, we aim to investigate how environmental triggers result in persistent alveolar damage.
Using CRISPR-Cas9 gene editing combined with hiPSC technology, we are developing a Birt-Hogg-Dube Lung-on-Chip model to study alveolar repair.
Epithelial - Immune cross-talk
Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.
Epithelial - Endothelial cross-talk
Using Organoid and Lung-Chip technology, we study how endothelial cells support the repair function of alveolar epithelial cells.
Using a variety of technologies, we study emphysematous lung tissue obtained before and after mesenchymal stem cell (MSC) therapy to identify markers of repair and/or altered immune responses.
We assess biomarkers to study effects of AAT therapy in patients with Alpha-1 Antitrypsin-related emphysema.