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Repair &
Regeneration

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Epithelial dysfunction

Epithelial Remodeling

We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD

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Epithelial dysfunction

Pulmonary fibrosis

We use Organoid and Transwell cultures to investigate the biology of radiation-induced lung fibrosis.

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Epithelial dysfunction

COVID-19 lung damage

We use primary alveolar cell cultures and organoid technology in combination with the Lung-Chip to develop a human cell culture model of COVID-19-related lung damage.

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Annemarie
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Epithelial Dysfunction

Alveolar damage

Using Lung-Chip technology combined with hiPSC and exposures, we aim to investigate how environmental triggers result in persistent alveolar damage.

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Epithelial Dysfunction

Birt-Hogg-Dube

Using CRISPR-Cas9 gene editing combined with hiPSC technology, we are developing a Birt-Hogg-Dube Lung-on-Chip model to study alveolar repair.

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Epithelial - Immune cross-talk

Severe Emphysema

Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.

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Epithelial - Endothelial cross-talk

Endothelial support

Using Organoid and Lung-Chip technology, we study how endothelial cells support the repair function of alveolar epithelial cells in the context of severe emphysema, also related to AATD.

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AATD

MSC therapy

Using a variety of technologies, we study emphysematous lung tissue obtained before and after mesenchymal stem cell (MSC) therapy to identify markers of repair and/or altered immune responses.

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Annemarie
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Regeneration

RecovAir

We take part in the REpairing lung damage via reCOVery of stromal heAlth to restore respIRatory function (RecovAir) consortium. We develop advanced lung-chip models to test new regenerative therapeutic strategies.

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