PulmoScience Lab
Repair &
Regeneration
Epithelial dysfunction
Epithelial Remodeling
We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD and Asthma
Epithelial dysfunction
Pulmonary fibrosis
We use Organoid and Transwell cultures to investigate the biology of radiation-induced lung fibrosis.
Epithelial dysfunction
COVID-19 lung damage
We use primary alveolar cell cultures and organoid technology in combination with the Lung-Chip to develop a human cell culture model of COVID-19-related lung damage.
Epithelial Dysfunction
Alveolar damage
Using Lung-Chip technology combined with hiPSC and exposures, we aim to investigate how environmental triggers result in persistent alveolar damage.
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Epithelial Dysfunction
Birt-Hogg-Dube
Using CRISPR-Cas9 gene editing combined with hiPSC technology, we are developing a Birt-Hogg-Dube Lung-on-Chip model to study alveolar repair.
Epithelial - Immune cross-talk
Severe Emphysema
Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.
Epithelial - Endothelial cross-talk
Endothelial support
Using Organoid and Lung-Chip technology, we study how endothelial cells support the repair function of alveolar epithelial cells.
AATD
MSC therapy
Using a variety of technologies, we study emphysematous lung tissue obtained before and after mesenchymal stem cell (MSC) therapy to identify markers of repair and/or altered immune responses.
AATD
Biomarkers
We assess biomarkers to study effects of AAT therapy in patients with Alpha-1 Antitrypsin-related emphysema.
