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Epithelial 

(dys)function

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Tissue damage

Epithelial Remodeling

We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD, ILD and lung cancer.

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Tissue damage

Pulmonary fibrosis

We use Organoid and Transwell cultures to investigate the biology of radiation-induced lung fibrosis.

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Tissue damage

COVID-19 lung damage

We use primary alveolar cell cultures and organoid technology in combination with the Lung-Chip to develop a human cell culture model of COVID-19-related lung damage.

Annemarie
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Tissue damage

AATD Biomarkers

We assess biomarkers to study effects of AAT therapy in patients with Alpha-1 Antitrypsin-related emphysema.

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Regeneration

MSC therapy

Using a variety of technologies, we study emphysematous lung tissue obtained before and after mesenchymal stem cell (MSC) therapy to identify markers of repair and/or altered immune responses.

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Lung cancer

Tumor Recurrence

Using Organoid and Lung-Chip technology, we study NSCLC tumor characteristics to identify patients at risk for recurrence.

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