Repair &
Regeneration
Epithelial dysfunction
Epithelial Remodeling
We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD
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Epithelial dysfunction
COVID-19 lung damage
We use primary alveolar cell cultures and organoid technology in combination with the Lung-Chip to develop a human cell culture model of COVID-19-related lung damage.
Epithelial Dysfunction
Alveolar damage
Using Lung-Chip technology combined with hiPSC and exposures, we aim to investigate how environmental triggers result in persistent alveolar damage.
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Epithelial Dysfunction
Birt-Hogg-Dube
Using CRISPR-Cas9 gene editing combined with hiPSC technology, we are developing a Birt-Hogg-Dube Lung-on-Chip model to study alveolar repair.
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Epithelial - Immune cross-talk
Severe Emphysema
Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.
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Epithelial - Endothelial cross-talk
Endothelial support
Using Organoid and Lung-Chip technology, we study how endothelial cells support the repair function of alveolar epithelial cells in the context of severe emphysema, also related to AATD.
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Regeneration
RecovAir
We take part in the REpairing lung damage via reCOVery of stromal heAlth to restore respIRatory function (RecovAir) consortium. We develop advanced lung-chip models to test new regenerative therapeutic strategies in COPD.
