Repair &
Regeneration
Epithelial dysfunction
Epithelial Remodeling
We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD and Asthma
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Epithelial dysfunction
Pulmonary fibrosis
We use Organoid and Transwell cultures to investigate the biology of radiation-induced lung fibrosis.
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Epithelial dysfunction
COVID-19 lung damage
We use primary alveolar cell cultures and organoid technology in combination with the Lung-Chip to develop a human cell culture model of COVID-19-related lung damage.
Epithelial Dysfunction
Alveolar damage
Using Lung-Chip technology combined with hiPSC and exposures, we aim to investigate how environmental triggers result in persistent alveolar damage.
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Epithelial Dysfunction
Birt-Hogg-Dube
Using CRISPR-Cas9 gene editing combined with hiPSC technology, we are developing a Birt-Hogg-Dube Lung-on-Chip model to study alveolar repair.
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Epithelial - Immune cross-talk
Severe Emphysema
Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.
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Epithelial - Endothelial cross-talk
Endothelial support
Using Organoid and Lung-Chip technology, we study how endothelial cells support the repair function of alveolar epithelial cells.
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AATD
MSC therapy
Using a variety of technologies, we study emphysematous lung tissue obtained before and after mesenchymal stem cell (MSC) therapy to identify markers of repair and/or altered immune responses.
AATD
Biomarkers
We assess biomarkers to study effects of AAT therapy in patients with Alpha-1 Antitrypsin-related emphysema.
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