Repair &
Regeneration
Epithelial Dysfunction
Birt-Hogg-Dube
Using CRISPR-Cas9 gene editing combined with hiPSC technology, we are developing a Birt-Hogg-Dube Lung-on-Chip model to study alveolar repair.
Epithelial - Immune cross-talk
Severe Emphysema
Using single cell and imaging mass cytometry (CyToF) technology we aim to characterize the immune landscape of emphysematous tissue.
Epithelial dysfunction
Epithelial Remodeling
We use primary epithelial cell cultures for studies on airway epithelial remodeling in COPD
Epithelial dysfunction
Toxicity
As part of the EFSA-TXG-MAP consortium we contribute to toxicogenomics mechanism-based AOP mapping for human NAM-based risk assessment with use of our primary and hiPSC -derived alveolar epithelial cell cultures.
Epithelial - Endothelial cross-talk
Endothelial support
Using Organoid and Lung-Chip technology, we study how endothelial cells support the repair function of alveolar epithelial cells in the context of severe emphysema, also related to AATD.
Regeneration
RecovAir
We take part in the REpairing lung damage via reCOVery of stromal heAlth to restore respIRatory function (RecovAir) consortium. We develop advanced lung-chip models to test new regenerative therapeutic strategies in COPD.
